Leaderboards
We evaluated the following FMs on the 6 supported WSI-classification tasks. We report Balanced Accuracy for binary & multiclass tasks and generalized Dice score (no background) for segmentation tasks. The score shows the average performance over 5 runs for patch-level classification & segmentation tasks, and 20 runs for slide-level (due to higher standard deviation among runs). Note the leaderboard orders from best to worst according to the average performance across all tasks, excluding BACH (not comparable due to much larger patch size).
The runs use the default setup described in the section below.
eva trains the decoder on the "train" split and uses the "validation" split for monitoring, early stopping and checkpoint selection. Evaluation results are reported on the "test" split if available and otherwise on the "validation" split.
For details on the FM-backbones and instructions to replicate the results, check out Replicate evaluations. For information on the tasks, check out Datasets. For Camelyon16 runtime optimization we use only 1000 foreground patches per slide which impacts the performance on this benchmark accross all models.
Evaluation protocol
eva uses a fixed protocol customized to each category of tasks. The setup has proven to be performant and robust independent of task and model size & architecture and generally prioritizes fairness and comparability over state-of-the-art performance.
We selected this approach to prioritize reliable, robust and fair FM-evaluation while being in line with common literature.
| WSI patch-level classification tasks | WSI slide-level classification tasks | WSI patch-level segmentation tasks | |
|---|---|---|---|
| Backbone | frozen | frozen | frozen |
| Head | single layer MLP | ABMIL | upscaling + conv with input image (3) |
| Dropout | 0.0 | 0.0 | 0.0 |
| Hidden activation function | n/a | ReLU | n/a |
| Output activation function | none | none | none |
| Number of steps | 12,500 | 12,500 (1) | 2,000 |
| Base batch size | 256 | 32 | 64 |
| Base learning rate | 0.0003 | 0.001 | 0.002 |
| Early stopping | 20% * [Max epochs] | 20% * [Max epochs] | 20% * [Max epochs] |
| Optimizer | AdamW | AdamW | AdamW |
| Momentum | 0.9 | n/a | n/a |
| Weight Decay | 0.0 | n/a | n/a |
| betas | n/a | [0.9, 0.999] | [0.9, 0.999] |
| Loss | Cross entropy | Cross entropy | Dice |
| number of patches per slide | 1 | dataset specific (2) | dataset specific (2) |
(1) Upper cap at a maximum of 100 epochs.
(2) Number of patches per slide depends on task and slide size. E.g. for PANDASmall and Camelyon16Small we use a max of 200 and 1000 random patches per slide respectively.
(3) Our custom segmentation decoder initially upsamples the input feature maps before concatenating them with the original input image, followed by a series of convolutional layers. Incorporating the input image is crucial to compensate for resolution loss in feature maps generated by architectures like ViT. Without this approach, models with smaller patch sizes would consistently outperform those with larger patch sizes in the leaderboard.